Family Guy is a series made by Seth MacFarlane, who also created Cavalcade of Cartoon Comedy.
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In S2e3 "Da Boom" Chris and Peter are barefoot after an explosion. So is Brian, but he's usually barefoot, since he's a dog.
In "lethal weapon" Lois and Bonnie (along with others) are barefooted while doing taijutsu.
S4e27 "Untitled Griffin Family History"
S5e6 "Prick Up Your Ears"
S10e10 "Meg and Quagmire"
Episode 179 Edit
S10e14 "Be Careful What You Fish For"
S11e12 "Valentine's Day in Quahog"
S12E06 "Life of Brian" In a alternate world where the Indians never lost their land, there's a Indian women who is barefooted as she did a pose when she asked the doctor if he did that to help her husband, who said that is offensive.